A body of literature has been accumulated over the last two decades that seeks to examine the role of inflammation in every stage of the atherothrombotic process. Research also indicates that the rupture of the ostensibly stable plaque is what results in most of the strokes and acute myocardial infarction. There are obviously several other reasons that can lead to the said strokes and acute myocardial infarction. And that is why it is necessary to test the hypothesis frequently.
What Do Other Reviews Have to Say?
Researchers have been looking into the causes of the condition since several years now, and the inflammatory hypothesis is just one potential cause for the issues we have mentioned above. Other factors that lead to premature atherosclerosis is that of the interaction of lipid accumulation and immune function. This results in the exposure of the underlying matrix to various thrombogenic factors. And this further leads to the condition we have been harping on for some time now.
How Promising is Anti-Inflammation Therapies?
The moot point of the research is the efficiency of anti-inflammation therapies and medication. Research is ongoing to check how promising they have been. It can be safely concluded that inflammation is one of the leading factors of vascular risks of sorts. And also, some anti-inflammatory therapies using animal models have shown promise. However, these results are still not enough to vouch for similar therapies and medication in human beings.
Some Clinical Evidence to Study:
Certain pieces of clinical evidence need to be taken into consideration while studying the hypothesis. A cohort of 20 studies indicates that high sensitivity C reactive protein can result in some cardiovascular events to recur. Also bringing about changes in lifestyle and opting for pharmacologic therapies minimize the risk of strokes and various other cardiovascular diseases. It has also been observed that drug therapies are successful in reducing LDL, but not hsCRP. These drugs have also failed to show promising results in randomized drug trials for reducing vascular risks.
The JUPITER Investigators:
One final thing that we need to note here is that of the JUPITER investigation. The investigation used inflammation as the primary entrant in the criteria for the research. This was based on the data that healthy people, with no prior records of cardiovascular issue or dangerous levels of LDL, have also suffered from strokes. The second stage observed the statins, which has also shown inflammatory properties. And in the final round of the study proved that statins help in lowering hsCRP and also mitigates issues of LDL.
It can be thus, stated that though inflammation is a major reason for cardiovascular diseases, it is not all that one needs to worry about. There are several other reasons for the issues. Therapies and medication are constantly looked into, and various conclusions have already been drawn out of the studies. There are still several possibilities to entertain, and that is why the inflammatory hypothesis of Atherothrombosis needs to be put under trials.